ABSTRACT
Vaccination is one of the most powerful measures to control infectious diseases. Nowadays, technical advances allowed the recognition of key aspects of pathogen -host interaction and the spread of such information, which was applied in vaccine development. The urge to control the COVID-19 pandemic resulted in vaccines development in record time, approximately 1 year after the emergence of SARS-CoV-2. The use of classic and innovative vaccine platforms and adjuvants was employed at several locations, by different groups. Here, we discuss how the pandemic scenario influences vaccine development, the implications of the route of immunization and adjuvant choice for vaccines, and the need to consider all these aspects in relation to the current scenario, also preparing ourselves to future pandemics. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
ABSTRACT
Antibody production in response to infection or vaccination is a crucial process to combat and prevent infectious diseases. Regarding SARS-CoV-2, different features have been observed and literature still lacks consensus about it. Here, we discuss the production of antibodies during SARS-CoV-2 infection and its therapeutic relevance. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.
ABSTRACT
Hospital treatment of children with congenital heart disease during the SARS-CoV-2 pandemic restricts their daily activities such as bathing, eating, studying, and leisure. The protocols of patient safety and hospital biosafety that aim to improve the care quality actions and infection control tend to generate a reality of anonymity, depersonalization, which exacerbates the presence of fear related to pain and the threat of death in patients and their families. In this context, the environments that symbolized essential care for life now come to be understood by the population, as a place of the great possibility of infection by the new coronavirus. This set of factors can affect the lives of children with heart disease, given the urgency of hospital therapy, negatively influencing the acceptance of interventions performed in this context. To reflect on these aspects, this study describes the professional experiences that occurred during the COVID-19 pandemic in 2020 provided by a Cardiovascular Health Care Residency program. It is a descriptive and qualitative study of professional experience reports. In this, it was observed that the interaction of children and companions became restricted to individuals who shared the same ward environment and with the team members during the interventions. Because of this, the occupational therapist is the qualified professional to identify disruptions in daily life, reflect and intervene in new ways to meet occupational demands, develop resources and adaptations that corresponded to the needs of each patient. © 2022 Universidade Federal de Sao Carlos. All rights reserved.